Megan Menzies creates paintings that capture uncanny moments, rich with atmosphere and emotion. Her work often presents surreal imagery, such as a head on the horizon, a tear in an ear, or a hard shoulder in the rain. Through drawing, painting, and writing, she explores themes of memory, personal experience, and storytelling. Menzies frequently focuses on ordinary moments imbued with a melancholic quality, where time seems to thicken, and small details become heightened and significant.

Before starting a painting, Menzies relies on an essential period of drawing, using charcoal for its flexibility. This medium allows her to keep up with her thoughts and imagination, quickly filling her studio with images. These drawings help her visualise numerous ideas at once, from which she draws narratives and makes connections that feed into her paintings.

A key motif in Menzies' work is the blushing cheek, representing heightened sensitivity, emotional vulnerability, and embarrassment. She is particularly interested in the psychology of blushing and its connection to painting—both being intricate expressions of emotion. While blushing is involuntary and painting deliberate, she sees both as muddled forms of expression, with each painting embodying a kind of "blush."